Aduro is collaborating with Lilly on the research, development and commercialization of novel immunotherapy products for autoimmune and other inflammatory diseases. Aduro’s cGAS-STING Pathway Inhibitor program aims to discover and develop inhibitors of the intracellular stimulator of interferon genes (STING) pathway, which can modulate the immune response associated with various autoimmune diseases. As part of the agreement, Lilly will gain access to novel molecules from Aduro that are designed to inhibit the cGAS-STING pathway. Aduro and Lilly will collaborate to advance these molecules, as well as others from Lilly, into clinical development.
Aduro is collaborating with Novartis on the research, development, and commercialization of novel cancer immunotherapy products targeting the STING pathway. ADU-S100, the first therapeutic in clinical development specifically targeting STING, is being evaluated in a clinical trial for the treatment of cutaneously-accessible tumors, such as breast, head-and-neck, and renal cell cancers as well as lymphoma and melanoma.
Aduro is collaborating with Merck (known as MSD outside the United States and Canada) under a worldwide license agreement for the development and commercialization of CD27 antibody agonists. Merck has selected an anti-CD27 antibody identified through Aduro’s B-select monoclonal antibody technology to advance into the clinic.
Aduro is collaborating with researchers at Johns Hopkins to develop next-generation therapeutic approaches by combining GVAX, LADD and cyclic dinucleotides in multiple cancer indications.
Aduro is partnering with The University of California (UC) Berkeley on the Immunotherapeutics and Vaccine Research Initiative (IVRI) to develop new immunotherapies for treating and preventing cancer, infectious disease, and autoimmune disease. The initiative combines UC Berkeley’s research capabilities with the company’s expertise in immunotherapy discovery and development.